TMAs

Investigators requesting access to view Tissue Microarray (TMA) images are required to complete the ACSR’s Virtual Biorepository Access Agreement.  High level groupings of TMAs are listed in the menu to the left which link to a brief description of the individual TMA images available for viewing online.  

Tissue Microarray (TMA) sections are distributed with an accompanying diagram.  The TMA diagram will show the relative placement of the patient and orientation/control cores. The investigator will also receive a Quality Assessment summary for the materials received.  This QA document will contain a pathologist’s review of the H&E for presence or absence of tumor and core, as well as documentation of biological stains done to assess the tumor and nucleic acid integrity of the core.  This QA may or may not have been done on a section near or adjacent to the sections you have received for your research. The percent of cores present is dependent upon the section number, the type of tissue and the method used to construct the TMA.

KS (HIV related) oral, visceral and skin from the U.S. and sub-Saharan Africa (SSA).  Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

          

  • SSA KS:  48 cores from 18 patients (12 control cores) Image
  • SSA KS:  48 cores from 18 patients (10  control cores) Image 
  • SSA KS:  56 cores from 22 patients (12  control cores)  Image
  • SSA Visceral: 11 cores from 8 patients (2 control cores)  Image 
  • SSA Skin:  35 cores from 32 patients (2  control cores)  Image 
  • SSA Skin: 12 cores from 9 patients (2 control cores)  Image 
  • SSA Skin: 30 cores from 27 patients (2 control cores) Image 
  • SSA Skin: 31 cores from 28 patients (2 control cores)  Image 
  • SSA Visceral: 12 cores from 9 patients (2 control cores)  Image 
  • SSA Oral: 12 cores from 9 patients (2 control cores)  Image 
  • Skin: 36 cores from 31 patients (4 control cores)  Image / Image 
  • Visceral: 33 cores from 28 patients (4 control cores)  Image / Image 
  • Oral: 24 cores from 19 patients (4 control cores) Image / Image 

Lymphoma (HIV related) from the U.S. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

  • Misc. Lymphoma: 54 cores from 50 patients (2 control cores) Image 
  • DLBCL HIV+: 58 cores from 54 cases (1 control cores) Image / Image 
  • DLBCL HIV+: 14 cores from 10 cases (3 control cores) Image 
  • DLBCL HIV+: 13 corehttp://DLBCL HIVpos TMA 5 2014 H&E stain from 10 cases (2 control cores) Image
  • Burkitt Lymphoma (BL) Bone Marrow (BM): 11 cores from 6 patients (3 control cores) Image 
  • Burkitt Lymphoma (BL): 32 cores from 17 patients (3 control cores) Image 
  • Burkitt Lymphoma (BL): 43 cores from 26 patients (3 control cores) Image

  

Lymphoma (HIV negative) from the U.S. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

 

 

  • PTLD: 23 cores from 22 cases (1 control core) Image / Image  
  • Misc Lymphoma: 56 cores from 52 cases (3 control cores) Image 
  • Misc lymphoma: 55 cores from 52 cases (2 control cores) Image 
  • DLBCL HIV negative: 43 cores from 38 cases (4 control cores) Image / Image 

 

 

Non-AIDS-defining Cancers (HIV related) from the U.S. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

  • Prostate Cancer HIV+: 20 cores from 18 cases (2 control cores) Image 
  • Prostate Cancer HIV+: 22 cores from 20 cases (2 control cores) Image 
  • PCNSL:  30 cores from 27 patients (3  control cores) Image 
  • PCNSL:  40 cores from 37 patients (3  control cores) Image 
  • Lung Cancer HIV+: 27 cores from 26 cases (1 control core) Image 
  • Lung Cancer HIV+: 28 cores from 27 cases (1 control core) Image 
  • Head and Neck 12 HIV+, 13 HIV-: 32 cores from 25 patient cases (1 of the 32 cores is an orientation core, 3 control cores) Image 
  • HD:  61 cores from 27 patients (1 control cores) Image
  • HD:  56 cores from 50 patients (1 control cores) Image 
  • Breast: 17 cores from 14 patients (3 control cores) Image
  • Anal Cancer HIV+ Invasive: 14 cores from 10 cases (3 control cores) Image 
  • Anal Cancer HIV+ Invasive: 40 cores from 36 cases (3 control cores) Image 
  • Anal Cancer HIV+ In situ: 11 cores from 7 cases (3 control cores) Image 
  • Anal Cancer HIV+ In situ: 23 cores from 19 cases (3 control cores) Image 
  • Anal Invasive TMA 1 2018: 25 cores from 21 cases Image
  • Anal Invasive TMA 2 2018: 21 cores from 17 cases Image
  • Anal InSitu TMA 3 2018: 15 cores from 11 cases Image
  • Lung Cancer TMA 1 2020; 41 cores from 20 cases Image
  • Lung Cancer TMA 2 2020; 41 cores from 20 cases Image
  • Anal Brazilian TMA 1 2021: 23 cores from 13 cases Image
  • Anal Brazilian TMA 2 2021: 23 cores from 13 cases Image
  • Anal Brazilian TMA 3 2021: 26 cores from 13 cases Image

Multsite Autopsies (HIV related non-Hodgkin lymphoma) includes involved and uninvolved tissues. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

  • NHL: 26 cores from 25 sites (1 control core) Image / Image 
  • NHL: 23 cores from 21 sites (2 control cores) Image
  • NHL: 34 cores from 31 sites (3 control cores) Image 
  • NHL: 23 cores from 21 sites (2 control cores) Image 
  • NHL: 35 cores from 32 sites (3 control cores) Image 
  • NHL: 35 cores from 34 sites (1 control core) Image / Image

 

Multsite Autopsies (HIV related Kaposi Sarcoma) includes involved and uninvolved tissues. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

 

  • KS: 21 cores from 20 sites (1 control core) Image 
  • KS: 22 cores from 21 sites (1 control core) Image 
  • KS: 20 cores from 19 sites (1 control core) Image / Image 
  • KS: 25 cores from 24 sites (1 control core) Image 
  • KS: 16 cores from 15 sites (1 control core) Image 
  • KS: 18 cores from 17 sites (1 control core) Image 
  • KS: 19 cores from 18 sites (1 control core) Image 

Multsite Autopsies (HIV related Lung Cancer) includes involved and uninvolved tissues. Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

  • Autopsy Lung TMA #15 2019: 19 cores from 1 case image
  • Autopsy Lung TMA #16 2019: 21 cores from 1 case image
  • Autopsy Lung TMA #17 2019: 20 cores from 1 case image

 

A randomized trial conducted from 2007 to 2011 to evaluate the efficacy of a protease inhibitor-based antiretroviral therapy regimen compared with a non-nucleoside reverse transcriptase inhibitor-based regimen to treat HIV-related histologically-confirmed KS in adults in Uganda. Data and biospecimens collected at multiple time points  from a cohort of >200 participants.  Examples of TMA images are provided in the "Image" links below. Please go to our ACSR Digital Library for the complete collection of TMA images.

 

  • ARKS TMA 1 2020 41 cores  from 37 cases image
  • ARKS TMA 2 2020 40 cores  from 36 cases image
  • ARKS TMA 3 2020 40 cores  from 36 cases image
  • ARKS TMA 4 2020 40 cores  from 36 cases image