ACSR Principal Investigators
Dr. Sylvia Silver earned her D.A. in 1977 from The Catholic University of America. Directing the operations of biorepositories for over 20 years, Dr. Silver currently serves as one of the MPIs to the AIDS and Cancer Specimen Resource, director of the AIDS Malignancy Clinical Trials Consortium domestic biorepository, and is the GW Cancer Center Biorepository Core Director. Dr. Silver lends her many years of biobanking expertise to other biobanks globally and participates on international advisory committees in need of assistance with biobank development.
RBR Site PIs
Dr. Ittmann holds the William D. Tigertt Chair of Pathology at the Baylor College of Medicine in Houston, Texas. He is a Board certified Anatomic pathologist with 33 years of experience in pathology and is Chief of Pathology and Laboratory Medicine at the Michael E. DeBakey VA Medical Center. He has carried out a funded research program in prostate cancer over the last 23 years resulting in 219 scientific publications. He also directs the Human Tissue and Pathology Core at Baylor College of Medicine. He is currently a member of the Cancer Biomarkers Study Section for the National Cancer Institute.
Dr. Maguire, the site PI of the ACSR Technical Core laboratory located at Mayo Clinic Arizona, joined the ACSR in 2017 under the mentorship of her predecessor, Dr. Lisa Rimsza. She is an Assistant Professor in Cancer Biology at Mayo Clinic School of Medicine and a recipient of an NIH P30 Cancer Center Supplemental Grant award to further her research into the genomic differences between Diffuse Large B-Cell Lymphomas arising in HIV positive patients compared to that which arises in uninfected individuals. Dr. Maguire has worked in translational research for almost 8 years and as such has keen understanding of how precious human tissues for research are. Dr. Maguire oversees the collection, processing and distribution of ACSR materials, and works with eligible investigators to meet their research needs whilst also adhering to the core principles of the ACSR; responsible custodianship and equitable distribution of materials.
Dr. Schneider is an anatomical pathologist with an interest in dermatopathology and HIV/AIDS related malignancies. Through his collaboration with the ACSR since 2009 he has gained experience and knowledge regarding the science and the operation of a biobank. Following a successful application in 2013, he became the PI of the NCI-supported Aids Malignancy Consortium (AMC) and ACSR Sub Saharan Africa Regional Biospecimen Repository at Stellenbosch University. His research focuses on priority research areas that are relevant to South Africa and Africa, including cancer with a focus on HIV-related malignancies such as Kaposi’s sarcoma, and cutaneous tuberculosis.
ACSR Key Personnel
Dr. Bethony is the Co-Investigator of the George Washington University ACSR and the biorepository for the NCI-funded AIDS Malignancy Clinical Trials Consortium (AMC). Dr. Bethony provides immunological and biorepository support for several ongoing vaccine clinical trials, including Phase 1 first-in-humans studies. He is actively involved in biospecimen science and has conducted several studies on the affect of storage duration and material types on the quality of derivatives from biobanked materials.
Dr. Bracci is a cancer epidemiologist at UCSF who has been actively involved in the design and conduct of population and clinic-based studies of cancer, particularly lymphoma, pancreatic cancer and glioma, for more than 20 years. She brings to the ACSR an expertise in study design and analysis methodology, and complementary research interests related to immunological factors associated with cancer risk and prognosis as well as the integration of Big Data into biorepositories.
Dr. Castro earned her PhD in 2001 from the University of Texas-Health Science Center in Houston, TX. Her career has focused on studying the genetics of cancer mutations and biology of leukemia and prostate cancer. Presently, she is the Laboratory Director of the Human Tissue Acquisition and Pathology (HTAP) Core at Baylor College of Medicine. Her role in HTAP is to facilitate the collection, processing and molecular analysis of human tissues as well as to manage services for histology, immunohistochemistry, and imaging of research tissues from mouse or human origin.