African

Samples and data from African collections are available through collaboration with the study PI Dr. Jeff Martin.
  • Antiretrovirals in Kaposi Sarcoma (ARKS)
  • Uganda AIDS Rural Treatment Outcomes (UARTO)
  • Epidemiology and Virology of KSHV in Zimbabwe
  • Transmission of KSHV to Children in South Africa

Antiretrovirals in Kaposi Sarcoma (ARKS): A randomized trial conducted from 2007 to 2011 to evaluate the efficacy of a protease inhibitor-based antiretroviral therapy regimen compared with a non-nucleoside reverse transcriptase inhibitor-based regimen to treat HIV-related histologically-confirmed KS in adults in Uganda. Data and biospecimens collected at multiple time points  from this cohort of >200 participants are depicted in the graphic. Click here for STUDY DETAILS

Uganda AIDS Rural Treatment Outcomes (UARTO): 
A prospective cohort study conducted from 2005 to 2010 to describe the virologic, immunologic, and clinical outcomes of antiretroviral therapy and factors associated with these outcomes among >700 adults recruited from a representative publicly funded municipal HIV/AIDS clinic in Mbarara, Uganda.  Specimens collected at multiple time points are depicted in the graphic. Click here for STUDY DETAIL

Epidemiology and Virology of KSHV in Zimbabwe: 
A cross-sectional study conducted from 2001 to 2004 that evaluated the prevalence and determinants of KSHV infection and the pattern of KSHV shedding among >400 HIV+ and >200 HIV- adult women in Zimbabwe. KSHV antibody results and questionnaire data collected via direct interview are available and include demographic data, information about adult and childhood personal behaviors relevant to transmission as well as housing/residential factors, sexual history and pregnancies. Specimens collected at are depicted in the graphic. Click here for STUDY DETAIL

Transmission of KSHV to Children in South Africa: A cross-sectional study conducted in 2001 to 2004 that evaluated the prevalence and determinants of KSHV infection and shedding among >200 HIV+ and >700 HIV- children aged 1.5 to <9 years and their primary caregiver in rural and urban settings in Africa. KSHV antibody results are available. Questionnaire data collected via direct interview are consistent with the data collected in the Zimbabwe KSHV study in our inventory and include demographic data, information about adult and childhood personal behaviors relevant to transmission as well as housing/residential factors, sexual history and pregnancies. Available specimens are depicted in the graphic. Click here for STUDY DETAIL

Domestic

ACSR Domestic Collection.

  • Women’s Interagency HIV Study (WIHS) donations
  • San Francisco Young Men’s Health Study (SFYMHS)

Women’s Interagency HIV Study (WIHS) donations: A longitudinal cohort study of HIV+ and HIV- adult women to characterize the long-term, natural and treated history of HIV infection and to provide insight into the changing demographics of the HIV epidemic in the United States. Data and biospecimen donations to the ACSR from 1400 women include plasma, PBMCs, saliva and a small number of cervical tissue samples that were collected at multiple time points from 1997 to 2015. Available biospecimens are depicted in the graphic. Click here for STUDY DETAIL

San Francisco Young Men’s Health Study: 
A population-based epidemiological risk factor study conducted in several ways among adult men who have sex with men in San Francisco. The cohort includes 581 men of varying status for HIV infection, KSHV infection, and KS. Data and biospecimens were collected at multiple time points from 1999 to 2002. Available specimens are depicted in the graphic. Click here for STUDY DETAIL

Multisite Autopsy

The ACSR has a collection of multi-site frozen/FFPE autopsies as a novel source of tissues from 57 individuals who had been living with HIV and had been diagnosed with cancer or other conditions.  Autopsy specimens are available from a spectrum of participants many within 6 hours of death, and most with multiple sites collected from cancer involved tissues as well as control uninvolved tissues.

Specimens available for Multisite Autopsy Collections.

General

The ACSR inventory includes various types and numbers of biospecimens donated by individuals living with and without HIV who are not part of the ACSR’s epidemiological and clinical studies collections. Included are samples collected pre- and post- HAART from patients diagnosed with AIDS-defining cancers, non-AIDS defining cancers, opportunistic infections and reactive processes.

Specimens available for General Collections.

Data Explorer

To access to the data within the ACSR’s Data Explorer we request that investigators complete the ACSR’s Data Explorer Access Agreement. The data generated are from extensive sequencing studies of HIV NEF within tissues from 25 different organ sites obtained from 13 patients included in the ACSR Autopsy Collection (five categories). The online data are searchable and viewable by disease/condition and tissue type. Additional information about the studies that generated these data can be obtained from the associated publications. The sequences also are posted online at GenBank and the Los Alamos HIV sequence database.

References for published HIV sequence data.

Tissue Microarrays (TMAs)

Investigators requesting access to view Tissue Microarray (TMA) images are required to complete the ACSR’s Image Access Agreement.  High level groupings of TMAs are listed in the boxes to the left which link to a listing and brief description of the individual TMAs for which images are available for viewing online.  

  • The ACSR Digital Library Guide is available to help investigators navigate the digital library.
  • Tissue Microarray (TMA) sections are distributed with an accompanying diagram.  The TMA diagram will show the relative placement of the patient and orientation/control cores. The investigator will also receive a Quality Assessment summary for the materials received.  This QA document will contain a pathologist’s review of the H&E for presence or absence of tumor and core, as well as documentation of biological stains done to assess the tumor and nucleic acid integrity of the core.  This QA may or may not have been done on a section near or adjacent to the sections you have received for your research. The percent of cores present is dependent upon the section number, the type of tissue and the method used to construct the TMA.

KS (HIV related) oral, visceral and skin from the U.S. and sub-Saharan Africa (SSA).  Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • SSA KS:  48 cores from 18 patients (12 control cores) Aperio Image Detail
  • SSA KS:  48 cores from 18 patients (10  control cores) Aperio Image Detail 
  • SSA KS:  56 cores from 22 patients (12  control cores) Aperio Image Detail 
  • SSA Visceral: 11 cores from 8 patients (2 control cores) Aperio Image / Detail
  • SSA Skin:  35 cores from 32 patients (2  control cores) Aperio Image Detail
  • KS:  229 cores from 113 patients (31 control cores with 4 cell lines) Aperio Image / Detail 
  • SSA Skin: 12 cores from 9 patients (2 control cores) Aperio Image / Detail
  • SSA Skin: 30 cores from 27 patients (2 control cores) Aperio Image / Detail
  • SSA Skin: 31 cores from 28 patients (2 control cores) Aperio Image / Detail
  • SSA Visceral: 12 cores from 9 patients (2 control cores) Aperio Image / Detail
  • SSA Oral: 12 cores from 9 patients (2 control cores) Aperio Image / Detail
  • Skin: 36 cores from 31 patients (4 control cores) Aperio Image Detail & Image / Detail
  • Visceral: 33 cores from 28 patients (4 control cores) Aperio Image / Detail ImageDetail
  • Oral: 24 cores from 19 patients (4 control cores) Aperio Image Detail & Image / Detail

Lymphoma (HIV related) from the U.S. Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • Misc. Lymphoma: 54 cores from 50 patients (2 control cores) Aperio Image Detail 
  • DLBCL HIV+: 58 cores from 54 cases (1 control cores) Aperio Image / Detail & Image / Detail
  • DLBCL HIV+: 14 cores from 10 cases (3 control cores) Aperio Image / Detail
  • DLBCL HIV+: 13 cores from 10 cases (2 control cores) Aperio Image / Detail
  • DLBCL HIV+: 143 cores from 117 patients (24 control cores) Aperio Image Detail
  • Burkitt Lymphoma (BL) Bone Marrow (BM): 11 cores from 6 patients (3 control cores) Aperio Image Detail
  • Burkitt Lymphoma (BL): 32 cores from 17 patients (3 control cores) Aperio Image Detail
  • Burkitt Lymphoma (BL): 43 cores from 26 patients (3 control cores) Aperio Image Detail

Lymphoma (HIV negative) from the U.S. Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • PTLD: 23 cores from 22 cases (1 control core) Aperio Image Detail & Image / Detail  
  • Misc Lymphoma: 56 cores from 52 cases (3 control cores) Aperio Image / Detail
  • Misc lymphoma: 55 cores from 52 cases (2 control cores) Aperio Image / Detail
  • DLBCL HIV negative: 43 cores from 38 cases (4 control cores) Aperio Image Detail & Image / Detail 

Non-AIDS-defining Cancers (HIV related) from the U.S. Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • Prostate Cancer HIV+: 20 cores from 18 cases (2 control cores) Aperio Image / Detail
  • Prostate Cancer HIV+: 22 cores from 20 cases (2 control cores) Aperio Image / Detail
  • PCNSL:  30 cores from 27 patients (3  control cores) Aperio Image / Detail 
  • PCNSL:  40 cores from 37 patients (3  control cores) Aperio Image Detail 
  • Lung Cancer HIV+: 27 cores from 26 cases (1 control core) Aperio Image / Detail
  • Lung Cancer HIV+: 28 cores from 27 cases (1 control core) Aperio Image / Detail
  • Head and Neck 12 HIV+, 13 HIV-: 32 cores from 25 patient cases (1 of the 32 cores is an orientation core, 3 control cores) Aperio Image / Detail
  • HD:  61 cores from 27 patients (1 control cores) Aperio Image Detail & Image / Detail 
  • HD:  56 cores from 50 patients (1 control cores) Aperio Image Detail 
  • Breast: 17 cores from 14 patients (3 control cores) Aperio Image Detail & Image / Detail
  • Anal Cancer HIV+ Invasive: 14 cores from 10 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ Invasive: 40 cores from 36 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ In situ: 11 cores from 7 cases (3 control cores) Aperio Image / Detail
  • Anal Cancer HIV+ In situ: 23 cores from 19 cases (3 control cores) Aperio Image / Detail

Multsite Autopsies (HIV related non-Hodgkin lymphoma) includes involved and uninvolved tissues. Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • NHL: 26 cores from 25 sites (1 control core) Aperio Image / DetailImage / Detail
  • NHL: 23 cores from 21 sites (2 control cores) Aperio Image / Detail
  • NHL: 34 cores from 31 sites (3 control cores) Aperio Image / Detail
  • NHL: 23 cores from 21 sites (2 control cores) Aperio Image / Detail
  • NHL: 35 cores from 32 sites (3 control cores) Aperio Image / Detail
  • NHL: 35 cores from 34 sites (1 control core) Aperio Image / Detail & Image / Detail

Multsite Autopsies (HIV related Kaposi Sarcoma) includes involved and uninvolved tissues. Examples of TMA Aperio images are provided in the "Image" links below. Please go to our Aperio ACSR Digital Library for the complete collection of TMA images.

  • KS: 21 cores from 20 sites (1 control core) Aperio Image / Detail
  • KS: 22 cores from 21 sites (1 control core) Aperio Image / Detail
  • KS: 20 cores from 19 sites (1 control core) Aperio Image Detail & Image / Detail
  • KS: 25 cores from 24 sites (1 control core) Aperio Image / Detail
  • KS: 16 cores from 15 sites (1 control core) Aperio Image / Detail
  • KS: 18 cores from 17 sites (1 control core) Aperio Image / Detail
  • KS: 19 cores from 18 sites (1 control core) Aperio Image / Detail